NLRP3 and neoplasm: Additionally, proteins related to the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome (i.e., NLRP3 and interleukin [IL]-1β) are preferentially present in the tumor specimens of VS-PH patients (13), while fibroblast growth factor 2 (FGF-2) is secreted at higher levels by VSs from patients with GH than PH (14).