In a recent case report on the use of ASL imaging, a patient with CJD with the D178N-129 M haplotype in the PRNP gene showed severe ASL hypoperfusion and DWI hyperintensity in the cerebral cortex, basal ganglia, and thalamus 6 months after the onset of neurological symptoms (36). This evidence concerns the gene PRNP and Creutzfeldt Jacob disease.