INS and Hyperglycemia: Patients experiencing weight loss and hyperglycemia with alarming levels of blood glucose (≥300 mg/dL [16.7 mmol/L]) or A1C (>10% [86 mmol/mol]) should be considered for an early introduction to insulin therapy.7., 8, 9. Studies also confirmed that insulin therapy was associated with a higher incidence of ADR due to the hypoglycemic tendency of its use.10