Analyses of kidney biopsies from patients with ADTKD‐UMOD revealed accumulation of uromodulin in the endoplasmic reticulum (ER) of TAL cells, suggestive of ER storage disease (Dahan et al, 2003; Rampoldi et al, 2003; Vylet'al et al, 2006). Here, UMOD is linked to autosomal dominant medullary cystic kidney disease with or without hyperuricemia.