Furthermore, the strong induction of lipocalin‐2 (LCN2) in the R186S kidneys may provide a link between ER stress, inflammation, and fibrosis, as LCN2 is a known homing factor for inflammatory cells and an active player in kidney disease progression (Viau et al, 2010; El Karoui et al, 2016). This evidence concerns the gene LCN2 and kidney disorder.