SBDS and cancer: Germline P/LP variants of SBDS, a pathogenic gene of Shwachman–Diamond Syndrome (SDS), have been found to be associated with an increased risk of myeloid malignancy [59, 60], and a recent study reported that a few of patients with malignant pleural mesothelioma carried germline truncation mutation of SBDS (p.K62*) [61].