SOD1 and amyotrophic lateral sclerosis: We provide evidence for the ability of GM1‐oligosaccharide (GM1‐OS) to prevent the neurodegeneration of an in vitro model of amyotrophic lateral sclerosis (ALS) by acting on crucial processes of disease pathophysiology (excitotoxicity, SOD1 aggregation, TDP43 mislocalization, mitochondria dysfunction, and oxidative stress).