Normally, farnesylated prelamin A is a transient species, essentially undetectable in cells because of its efficient conversion to mature lamin A. The premature aging disease Hutchinson–Gilford progeria syndrome (HGPS) is caused by a splicing mutation in LMNA that generates an internally deleted prelamin A variant called progerin or ∆50 prelamin A, but normal lamin C [23,24]. Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.