The cuproptosis cluster A had a longer 5‐year OS, higher alive status and lower TNM stage than cluster B and C. We found the cuproptosis cluster‐A was markedly enriched in metabolism, biosynthesis, and immunity, including drug metabolism cytochrome P450, tryptophan metabolism, PPAR signaling pathway, and primary immunodeficiency, all of these were involved in the TME of tumors. The gene discussed is PPARA; the disease is inborn error of immunity.