Activated CD8 T cells is involved in anti‐tumor immunity, CD8 T cell exhaustion affects anti‐tumor effects and the mechanism is complex,49 early‐relapse HCC have decreased levels of Tregs, increased DCs and infiltrated CD8+ T cells, exhausted CD8+ T cells have become the focus of anti‐tumor immunity research.50 This evidence concerns the gene CD8A and hepatocellular carcinoma.