The mRNA expression of 16 CRGs was detected in normal and HCC samples, the expression of FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1, MTF1, GLS, CDKN2A, DLST and ATP7A was higher in tumor, the expression of PDHB, DBT, GCSH, SLC31A1 and ATP7B was lower in tumor (Figure 1D). The gene discussed is SLC31A1; the disease is hepatocellular carcinoma.