CEBPD and leukemia: Leukemia cell lines treated with bortezomib, resulted in upregulation of CCAAT/enhancer binding protein delta (CEBPD) and induced multiple miRNAs such as MIR3154 amongst others, which were shown to target the 5’-flanking region of CEBPD and resulted in epigenetic gene silencing, consistent with a new mechanism in miRNA-mediated gene regulation [47].