TNF and hypersensitivity reaction disease: This inflammatory process is precipitated by perivascular immunoglobulin (Ig) deposition (Gell and Coombs classification type III hypersensitivity reaction) [3–5], followed by activation of the immune cascade, including chemokine release [interleukins (IL), tumor necrosis factor (TNF)], adhesion and extravasation of leukocytes [6].