CERS4 and breast cancer: Unlike prior studies that have investigated the roles played by CerS family members in breast cancer using transient overexpression [24], in the present study, the molecular effects of long-term CerS4 overexpression on breast cancer progression and migration were explored using TCGA-BRCA data, MCF-7 cells stably overexpressing CerS4 (MCF-7/CerS4), and doxorubicin-resistant MCF-7 (MCF-7/ADR) cells.