This transition has been reported in patients with Leydig cell tumors [17–24], adrenal tumors [25–31], congenital adrenal hyperplasia [32–35], overy granulosa cell tumors [36–38], familial male-limited PP [39, 40], McCune-Albright syndrome [41] and pineal mature teratoma [42], probably due to the circulating sex steroid hormones’ suddenly reduced feedback inhibition on gonadotropin releasing hormone and gonadotropins. This evidence concerns the gene PLXNA3 and congenital adrenal hyperplasia.