HIF1A and neoplasm: Our in vitro data from glucose and lactose detection kits, CCK-8, RT-PCR and transwell assays further confirmed that EVE and HIF-1α inhibitor, 2-Methoxyestradiol (2ME2) inhibited the glucose uptake (Fig. 5B), lactic acid (LD) secretion (Fig. 5C), survival (Fig. 5D), polarization (Fig. 5E) and pro-tumor migration function (Fig. 5F) of TAMs.