IL1R1 and congenital isolated hyperinsulinism: This study provides further insight into IL-1R1 function in amplifying the neuroinflammatory cascade following CHI in mice and demonstrates that suppression of IL-1R1 signaling offers long-term protective effects on brain health that is likely independent of its transient effects on inflammatory gene expression in the acute period, as IL-1R1 appears to be an early but transient mediator of post-injury gene inflammatory expression, particularly during the 9 h post-injury timeframe.