Under a SSc context, the inflammatory macrophages secrete cytokines and mediators like inducible nitric oxide synthase (iNOS), reactive oxygen species (ROS), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6), thus establishing a microenvironment supportive of fibroblasts proliferation and excessive collagen accumulation [2, 4]. The gene discussed is NOS2; the disease is systemic sclerosis.