In conclusion, we describe the male patient with PB-DLBCL, the non-GBC type, dual-expression type, with IgH/BCL6 fusion, nonsense mutation in TNFAIP3, frameshift mutations in PRDM1, missense mutations in CREBBP, DTX1, and FOXO1. This evidence concerns the gene PRDM1 and diffuse large B-cell lymphoma.