The role of SIRT3 in the progression of NASH is related to its deacetylation PTM action on manganese superoxide dismutase (Mn-SOD or SOD2) and the Nucleotide-binding Oligomerization Domain (NOD)-like receptor family pyrin domain containing 3 (NLRP3) inflammasome. This evidence concerns the gene SOD2 and metabolic dysfunction-associated steatohepatitis.