Multivariate logistic analysis results showed that elevated serum CEA level, peritumoral fat space invasion and positive pathological vascular tumor thrombus were significantly independent factors for disease recurrence of HAS patients after radical surgical resection, with OR were 10.87 (95%CI, 1.14–103.66, P = 0.003), 6.83 (95%CI, 1.08–43.08, P = 0.041) and 42.67 (95%CI, 3.66–496.85, P = 0.038), respectively (Table 3). The gene discussed is CEACAM5; the disease is vascular neoplasm.