Biological analysis using GSEA software showed that the citrate cycle tca cycle is active in the high-risk group, while apoptosis, B cell receptor signaling pathway, chemokine signaling pathway, citrate cycle tca cycle, intestinal immune network for IGA production, JAK STATsignaling pathway, MAPK signaling pathway, melanoma, natural killer cell mediated cytotoxicity, pathways in cancer, primary immunodeficiency, regulation of actin cytoskeleton, T cell receptor signaling pathway, VEGF signaling pathway are active in the low-risk group (Fig. 7A). Here, VEGFA is linked to inborn error of immunity.