The results showed that knocking down HLA-DQA1 substantially improved the survival of melanoma cells compared to the control group, as illustrated in Fig. 9B and C. Moreover, the downregulation of HLA-DQA1 significantly enhanced melanoma cell invasion, as illustrated in Fig. 9D. In addition, the scratch closure rate of melanoma cells transfected with siHLA-DQA1 was significantly higher than that of the control group after 24 h of plating, suggesting a significant enhancement in their migratory ability (Fig. 9E). This evidence concerns the gene HLA-DQA1 and melanoma.