In addition, important tumor pathways such as Wnt, MAPK, PI3K/AKT, TGF-beta, NF-kB, Notch, AMPK, JAK-STAT, PD-1/PD-L1, mTOR, Ras, TNF, HIF-1, ErbB are also associated with the risk score, and pathways and functions are correlated as well. This evidence concerns the gene TNF and neoplasm.