In oral cancer and breast cancer, HLA-DQA1 polymorphism is related to incidence, and high levels of expression are associated with better prognosis, offering potential biomarkers for prediction and treatment of oral cancer and breast cancer (Tsai et al. 2011; Zhou et al. 2023; Mahmoodi et al. 2012). The gene discussed is HLA-DQA1; the disease is breast cancer.