The common (23.3%) intron variant rs59237858-T in SCN1A that confers protection against epilepsy27 confers risk of migraine (OR = 1.031, P = 8.6 × 10−6) in our data, and rs62151809-T (44.7%) near TMEM182 confers risk of epilepsy27 and of VD in our data (OR = 1.047, P = 8.5 × 10−6). This evidence concerns the gene TMEM182 and sexually transmitted disease.