However, on the basis of previous functional studies40, the gene’s known function as a key component of the Ca2+-dependent neurotransmitter release machinery41, and its reported links to rare paroxysmal brain disorders including infantile convulsions, the movement disorder PKD and FHM42, in addition to the findings in this current study, we conclude that PRRT2 is also a risk gene for the common forms of MA and epilepsy. Here, PRRT2 is linked to microtia.