ASTN2 and migraine disorder: All MO-associated variants are in known migraine loci except the new MO-associated variant rs71642605-C in MANEAL. We find that one of the MO-associated variants, rs12684144-C in ASTN2, confers protection against VD (OR = 0.956, P = 0.00017) but risk of MO (OR = 1.073, P = 1.5 × 10−5).