KCNK5 and migraine disorder: In the GWAS meta-analysis of BRH, there is an association with a large protective effect (OR = 0.697, P = 7.6 × 10−14) with the rare (0.67%) intergenic variant rs72854118-G located in a regulatory region between two potassium channel genes, KCNK5 and KCNK17. The variant also protects against clinically defined migraine (OR = 0.836, P = 9.7 × 10−7), but does not associate with migraine subtypes, MA, MO or VD (P > 0.05).