LRRK2 and migraine disorder: However, consistent with our results showing that the variant in LRRK2 associates with increased risk of VD (MA) and with reduced LRRK2 mRNA expression, the main adverse effects of this LRRK2 inhibitor in healthy individuals were headache (40% of participants) and nausea (13%), the main symptoms of migraine, and dizziness (in 13%)51.