Upon thorough literature searching for the reports identifying the association of the TERT*(rs2736098 and rs2736100) variants with the progression of hepatocellular carcinoma, our team confirmed that this work is the innovative one for testing the correlation of the TERT*(rs2736100; c.1574-3777G > T) variant with elevated risk of HCC among Egyptian subjects. Here, TERT is linked to hepatocellular carcinoma.