The genes CDHR1, INPP5E, BBS1, SLC7A14 and LRP5 which showed strong interactions with high myopia and neuropsychiatric disorders were identified in patients 90, 91, 93 and 96, respectively, all of which have an impact on retinal nutrition and function, thus supporting the hypothesis that retinal dysfunction may play a role in the pathogenesis of some cases of SAD30. The gene discussed is LRP5; the disease is myopia.