Quercetin has been shown to activate the Hippo pathway and inhibit YAP signaling17, and sesquiterpene derivatives have been reported to induce ROS- and TRAIL-mediated apoptosis, enhance chemotherapy responses, and inhibit EMT with these effects being accompanied by the downregulation of β-catenin in CRC cells18. Here, TNFSF10 is linked to colorectal carcinoma.