In particular, Hutchinson–Gilford Progeria Syndrome (HGPS), a devastating premature aging disease, is mainly caused by a point mutation in exon 11 of the LMNA gene, G608G (GGC > GGT), resulting in a cryptic splicing event and generating a truncated product called progerin5. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.