The T58 degron of N-Myc is found at the binding interface of the complex formed by the Aurora kinase A (AurA) and N-Myc, thus the interaction of N-Myc with AurA inhibits its ubiquitinylation in neuroblastoma by blocking the interaction of N-Myc with the E3 ubiquitin ligase SCFFbxW717,18. This evidence concerns the gene AURKA and neuroblastoma.