The CNV percentage in pan-cancer indicated that heterozygous amplification in cancers were widely found in genes PTPN1, PTPN7, PTPN12 and PTPN14 in most cancers, while heterozygous deletions were widely found in genes PTPN13, PTPN20, PTPN22 and PTPN23 (Fig. 1b). Here, PTPN22 is linked to cancer.