Interestingly, Ivory is depleted of DEGs but is enriched for genes significantly associated with the expression of each three symptoms in males (Fisher Exact Test (FET): change in appetite/weight, padj < 1.0E−18; insomnia/hypersomnia, padj < 5.0E−11; difficulty in concentration/indecision padj < 5.0E−17) (Fig. 4e), including all three hub genes, namely, GAD1 and GAD2 which encode glutamate decarboxylase 1 and 2 and NXPH1 which encodes neurexophilin 1 (Fig. 4a). This evidence concerns the gene GAD1 and insomnia measurement.