CLSTN3 and major depressive disorder: In fact, 39% of all genes in Darkorange are associated with the expression of this symptom in female MDD (padj<5.0E−26), including the seven hub genes among which, CLSTN1 and CLSTN3 encoding transmembrane protein calsyntenin family members and PIK4KA encoding phosphatidylinositol (PI) 4-kinase were also significantly downregulated in the aINS of females with MDD (Fig. 5a).