In the OFC, hub genes in the Orange module encoding the glycogene synthase kinase 3 (GSK3B) and the GABA receptor subunit ß3 (GABRB3) were specifically associated with the expression of difficulty in concentration/indecision in male MDD, while hub genes encoding synpatojanin 1 (SYNJ1) and the clathrin coat assembly protein AP180 (SNAP91) drove the same associations in women. The gene discussed is SYNJ1; the disease is major depressive disorder.