INS and neoplasm: Insulin administration significantly increased 18F-FDG uptake in tumor tissue (Fig. 2a), liver (Fig. 2d), and heart (Fig. 2g) in diabetic animals but did not have a significant impact on 18F-FDG uptake in blood (Fig. 2b), skeletal muscle (Fig. 2c), kidneys (Fig. 2e), and brain (Fig. 2f).