FLCN and neoplasm: To examine whether the TFEB/TFE3-mTORC1 signaling is sufficient for TAM reprogramming to inhibit MYC-PyMT tumor growth, researchers further knockout FLCN or Rag GTPase in TAM by generating Fcgr1-cre-Flcnfl/fl and Fcgr1-cre-Rragafl/flRragbfl/fl mice, and found the enhanced mTORC1 signaling of TAM inhibit tumor growth even under normal diet conditions.