TFE3 and cancer: To confirm the role of TFEB/TFE3 in macrophage engulfment, they performed myeloid-specific knockout of TFEB/TFE3 or RPTOR with Fcgr1-Cre mouse, which led to suppressed mTORC1 signals of TAMs but restored mTORC1 and growth signals of cancer cells (Fig. 1).