CXCL12 and neoplasm: CellChat predicted active chemoattractant signaling from perivascular fibroblasts to macrophages via chemokines CCL2, CXCL1, CXCL2, CXCL12, CSF1, and matricellular protein periostin (POSTN), which are known to induce chemotaxis and alternative polarization of tumor-supporting M2-like myeloid cells (Fig. 3d–f)3,40–44.