Cardiac-specific FTO-cKO deteriorates transverse aortic constriction (TAC) surgery-induced HFrEF in mice.328 In turn, overexpression of FTO attenuates TAC-induced cardiac hypertrophy and HF.329 Dorn et al.330 found that METTL3 overexpression induces a compensatory cardiac hypertrophy phenotype without pathological changes, even under stress stimuli such as pressure overload. This evidence concerns the gene METTL3 and cardiac hypertrophy.