In diabetic cardiomyopathy, METTL14 is down-regulated and mediates CM pyroptosis via the NLRP3-caspase-1 pathway.324 Functionally, METTL14-mediated hypermethylation of lncRNA TINCR promotes TINCR decay through YTHDF2, which weakens the inhibition of TINCR on the target NLRP3. The gene discussed is NLRP3; the disease is diabetic cardiomyopathy.