HuR is reduced in the aorta of patients with hypertension, and specific HuR-cKO mice develop hypertension and cardiac hypertrophy.301 HuR reportedly binds to AREs in caveolin-1 mRNA and soluble guanylyl cyclase (sGC) mRNA and regulates BP.301,302. This evidence concerns the gene ELAVL1 and hypertensive disorder.