THUMPD1 and malignant colon neoplasm: It regulates ribosome biogenesis, but the exact mechanism remains to be investigated further.186 A recent study reported that SNORD13 assists ac4C1842 in 18S rRNA, but the mechanism has not been clarified.187 In human colon cancer cells, NAT10 depletion significantly reduces tRNA acetylation.188 Moreover, the NAT10-THUMPD1 complex is responsible for acetylating human tRNA, whereas THUMPD1 primarily acts as a tRNA adapter.