Finally, the authors explored the impact of polyamines on the transcriptome and chromatin landscape of PDA using RNA- and ATAC-sequencing.5 Silencing OAT or ODC1 resulted in more differentially expressed genes, compared to ARG2 knockdown and unsupervised clustering showed that silencing OAT had greater transcriptional similarity to ODC1 knockdown. This evidence concerns the gene ODC1 and Patent ductus arteriosus.