OAT and Patent ductus arteriosus: Finally, the authors explored the impact of polyamines on the transcriptome and chromatin landscape of PDA using RNA- and ATAC-sequencing.5 Silencing OAT or ODC1 resulted in more differentially expressed genes, compared to ARG2 knockdown and unsupervised clustering showed that silencing OAT had greater transcriptional similarity to ODC1 knockdown.