A study performed in the United Kingdom identified several TCGA hot spot mutations in well-known cancer driver genes such as KRAS, BRAF, ERBB2, ERBB3, TP53, and FBXW7 in non-dysplastic mucosa, corroborating other reports of TP53 and KRAS mutations in nondysplastic IBD colon, albeit at low frequency [14, 19, 20]. This evidence concerns the gene TP53 and cancer.