The other mainstays of IBD treatment such as tumor necrosis factor-alpha inhibitors and corticosteroids, or other agents found to be chemopreventive for sporadic colorectal cancer such as nonsteroidal anti-inflammatory drugs, acetylsalicylic acid, folic acid, statins, or calcium supplements, were not associated with a lower risk of colorectal neoplasia in the setting of chronic colitis [3]. Here, TNF is linked to inflammatory bowel disease.