Instead, they identified only four genes exhibiting a high non-synonymous to synonymous mutation ratio in non-dysplastic IBD, including PIGR, ZC3H12A, and two tumor suppressors, the SWI/SNF family chromatin remodeling gene ARID1A and the ubiquitin ligase complex gene FBXW7 [14]. The gene discussed is ZC3H12A; the disease is inflammatory bowel disease.