HPSE and plasma cell myeloma: Yang et al. reported that heparanase can promote the homing of myeloma and osteolysis cells by upregulating the expression and secretion of RANKL.198,199 Esposito et al. demonstrated that the interaction of Golgi glycoprotein 1 (Glg1) with E-selectin plays a key role in mediating bone metastasis of tumors.200