Of these, IL-2 [SMD = 1.29 (95% CI: 0.61–1.97; P <0.001)], IL-17 [SMD = 0.71 (95% CI: 0.12–1.30; P = 0.018)], IL-18 [SMD = 1.27 (95% CI: 0.64–1.90; P <0.001)], and IFN-γ [SMD = 1.90 (95% CI: 1.27–2.52; P <0.001)] levels had significant correlations with psoriasis. The gene discussed is IL18; the disease is psoriasis.