Similar to murine 4TO7 breast cancer, Gsdmc sensitized tumor cells to PARPi in BRCA-proficient parental cells, whereas greater tumor inhibition was shown in BRCA-KO cancer cells with Gsdmc expression in PanO2, MC38, Hepa-1-6, and B16 cells (Figure 5I). The gene discussed is GSDMC; the disease is cancer.