GSDMC and neoplasm: Similar to 4TO7 cells, Gsdmc-WT expression in 4TO7-Brca–KO cells did not slow down PARPi-treated tumor growth compared with Gsdmc-mut or vector in nude mice (Figure 2E and Supplemental Figure 3, B and C), but promoted superior tumor clearance in immunocompetent mice (Figure 2F), with enhanced CCP (Figure 2G).