GSDMC and melanoma: To ascertain the universality of GSDMC-enhanced PARPi sensitivity in cancers, we stably enforced Gsdmc expression in parental and Brca-KO murine cancer cells, including PanO2 pancreatic cancer, MC38 colorectal cancer, Hepa-1-6 liver cancer, and B16 melanoma cells (Supplemental Figure 7, D and E).