Increased sensitivity of PARPi by GSDMC was neither observed in human cell line MDA-MB-436 xenograft tumor model (Figure 2A), nor in mouse cell line, 4TO7 (Figure 2B) that was ectopically expressed Gsdmc-WT or Gsdmc-mut (Supplemental Figure 3A). This evidence concerns the gene GSDMC and neoplasm.