HLA-A and uveal melanoma: In a US cohort, the HLA-A2 subtype was present in 35% of African American individuals and 50% of White individuals.15 In participants with HLA-A2, the HLA-A*02:01 subtype was the most common, with variation across racial groups (53% in Asian or Pacific Islander individuals and ≤96% in White individuals).15 Therefore, from an individual patient perspective, being diagnosed with uveal melanoma offers unequal opportunities to HLA-restricted therapies according to one’s racial and ethnic background.