Many of these patients are diagnosed with high-grade B-cell lymphoma with MYC and BCL2 rearrangement (HGBL-MYC/BCL2; refs. 6, 7) a subtype also known as double-hit diffuse large B-cell lymphoma (DH-DLBCL; refs. 8, 9). Here, BCL2 is linked to diffuse large B-cell lymphoma.