However, the association between sepsis and APOL1 high-risk genotypes was not significant after adjustment for pre-existing severe renal disease (OR = 1.14 [95% CI: 0.88–1.48; p=0.33]), nor after exclusion of those patients (n=458) with severe renal disease (OR = 0.99 [95% CI, 0.70–1.39; p=0.95]) (Figure 2). This evidence concerns the gene APOL1 and Sepsis.