APOL1 and kidney disorder: The association between high-risk APOL1 genotypes and the renal dysfunction component of the Sepsis-3 criteria was markedly attenuated by adjusting for pre-existing severe renal disease present in the year before the index hospital admission (Figure 2, OR = 1.36 [95% CI, 1.00–1.86; p=0.05]) and was nullified after the exclusion of patients with pre-existing severe renal disease (Figure 2, OR = 1.16 [95% CI, 0.74–1.81; p=0.52]).