APOL1 and kidney disorder: More specifically, since APOL1 is associated with renal disease (Foster et al., 2013; Bajaj et al., 2020; Yusuf et al., 2021; Chen et al., 2021) and existing renal disease is associated with worse sepsis outcomes (Doi et al., 2008) (including increased kidney injury), the relationship between APOL1 and sepsis external to existing renal disease remains unclear.