Whether different entry routes lead to different infection outcomes is unknown, although some evidence for this exists; nuclear import pathway has been linked to integration and replication efficiency (38), interferon induced transmembrane protein (IFITM) sensitivity of HIV-1 strains is determined by the co-receptor usage of the viral envelope glycoproteins (39), and nuclear entry mechanism has been shown to affect the potency of the restriction factor Mx2/MxB (40). Here, MX2 is linked to infection.