Zhang and Bieniasz identified coiled-coil domain containing 137 (CCDC137) as a target of Vpr that when depleted not only more closely mimicked the HIV-1 infection-triggered Vpr-mediated G2/M cell cycle arrest but also produced the enhanced HIV-1 gene expression (94), suggesting it is a core Vpr target. This evidence concerns the gene CCDC137 and HIV-1 infection.