To identify TRIM genes associated with the treatment response to PegIFNα treatment, we treated HepAD38 and HepG2.2.15 cells, which are hepatoblastoma cells stably transfected to express HBV, with 1,000 IU/mL PegIFNα or with phosphate-buffered saline (PBS) for 24 hours (the cell lines contain 1.1 times the HBV genome and two times the HBV genome linked head to tail, respectively). The gene discussed is TRAT1; the disease is hepatoblastoma.