TMEM106B and amyotrophic lateral sclerosis: A recent study reported that two FTD-ALS genes, C9orf72 and TBK1, converge on the endolysosomal pathway to induce TDP-43 pathology and degeneration.29 While our study focuses on VCP, several other genes associated with FTD and ALS, such as CHMP2B,42GRN43 and TMEM106B,44 have been shown to affect the endolysosomal system.