A recent study reported that two FTD-ALS genes, C9orf72 and TBK1, converge on the endolysosomal pathway to induce TDP-43 pathology and degeneration.29 While our study focuses on VCP, several other genes associated with FTD and ALS, such as CHMP2B,42GRN43 and TMEM106B,44 have been shown to affect the endolysosomal system. The gene discussed is TARDBP; the disease is frontotemporal dementia.