Intriguingly, CASP8 was one of the most frequently mutated gene only inthe Scissorhigh group, while SYNE1 only discovered in the Scissorlow group (Figure 3A), suggesting that mutation frequency of CASP8 and SYNE1 play an potential role to predict the prognosis in HNSCC. This evidence concerns the gene CASP8 and head and neck squamous cell carcinoma.