Intriguingly, CASP8 was one of the most frequently mutated gene only inthe Scissorhigh group, while SYNE1 only discovered in the Scissorlow group (Figure 3A), suggesting that mutation frequency of CASP8 and SYNE1 play an potential role to predict the prognosis in HNSCC. The gene discussed is SYNE1; the disease is head and neck squamous cell carcinoma.