DNMT3B was frequently implicated in normal physiological development and cancer genetic mutations. Recent emerging evidence indicated that epigenetic alteration caused by DNMT3B abnormalities, like TCF3 silencing in endometrial cancer12 and CTH downregulation in hepatocellular carcinoma,13 was associated with tumorigenesis and tumor progression. This evidence concerns the gene DNMT3B and hepatocellular carcinoma.