The INO80 gene was identified as another candidate for microcephaly and it has been shown to play a role in the HR pathway, mediating the removal of histone subunit H2A.Z, and exchanging RPA for RAD51, which are crucial steps in the DSB repair (Shaheen et al., 2014; Alatwi and Downs, 2015; Alazami et al., 2015; Morrison, 2017; Keil et al., 2020). Here, INO80 is linked to microcephaly.