Leukocytosis, elevated CRP, genotyping: HLA-B*1518/B*4001, skin biopsy: there was marked liquefactive degeneration in the lower half of the epidermis with some dyskeratotic keratinocytes. The dermis showed predominant CD8+ lymphohistiocytic infiltration around the blood vessels and scanty eosinophils. The gene discussed is HLA-B; the disease is Increased total leukocyte count.