In PRP, intra-dermal injection of activated platelets release growth factors near HFs (21), including transforming growth factor-β (TGF-β), epidermal growth factor, basic fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and insulin-like growth factor-1, which support the anagen phase of the hair cycle. This evidence concerns the gene VEGFA and Hand-foot syndrome.