RELN and Lissencephaly syndrome, Norman-Roberts type: These include the monogenic conditions provoked in humans by the RELN gene,i.e., lissencephaly 2 (LIS2) and autosomal-dominant lateral temporal epilepsy (ADLTE), and a series of pathologies related to genes encoding for the proteins of the Reln intracellular cascade or only tentatively linked to RELN.11