FDFT1 and colorectal carcinoma: Moreover, a recent study found that fasting inhibits glycolysis as well as cell proliferation in CT26 cells and upregulates Farnesyl-Diphosphate Farnesyltransferase 1 (FDFT1), thereby inhibiting AKT/mTOR/HIF1α signaling, which then further affects glycolysis in CRC (127).