TRAP1 and cancer: Silencing TRAP1 in HCT116 cells led to a decrease in GLUT1 expression, reduced lactate production, and at the transcriptional level, suppression of HIF-1α-driven reprogramming of gene expression in cancer cells, indicating that TRAP1 is a possible key factor in maintaining HIF-1α-induced gene/metabolic reprogramming under hypoxic conditions (139).