For example, melatonin combined with hyperbaric oxygen therapy (HBO) inhibits the degree of AKT activation induced by oncogenic mutations in CRC, subsequently decreasing the expression of HIF-1 and downregulating the expression of glycolysis-related enzymes (HK2/PFK1/PKM2/LDH), limiting tumor development (147). This evidence concerns the gene PFKM and colorectal carcinoma.