PINK1 and colorectal carcinoma: Recently, it was found that the expression of PTEN-induced kinase 1 (PINK1) was lower in the colon tissue of CRC patients than in the normal population and that disruption of PINK1 increased the probability of colon tumorigenesis in an IBD-related CRC mouse model, suggesting that PINK1 has a tumor suppressor role in CRC (132).