In LPS and IFN-γ stimulated bone marrow-derived macrophage (BMDM) cell models of inflammation, mRNA expression of glycolytic enzyme genes, including glucose transporter protein 1 (GLUT1), enolase 1 (ENO1), pyruvate kinase (PKM), pyruvate dehydrogenase kinase 1 (PDK1), aldolase, lactate dehydrogenase A (LDHA), phosphoglycerate mutase (PGAM), phosphofructokinase (PFK), and glyceraldehyde-3-phosphate dehydrogenase (GhAPDH) were significantly elevated, indicating that glycolysis in macrophages is significantly elevated in the IBD state. This evidence concerns the gene PKM and inflammatory bowel disease.