It was found that GOLPH3 activates mTOR signaling through phosphorylation of mTORC1 and mTORC2 specific substrates, thus, STK25 affects mTOR signaling through GOLPH3 and inhibits CRC cell proliferation and glycolysis, thereby retarding the development of CRC (126). The gene discussed is STK25; the disease is colorectal carcinoma.