Earlier animal studies with malnourished mothers reported that delayed ossification is associated with decreased maternal body weight, and maternal malnutrition or reduced intake are common pathways to decreased fetal weight/growth and ossification (66–69), but malnutrition models did not report the increase in major congenital anomalies reported after gestational exposure to GLP-1 agonists. This evidence concerns the gene GLP1R and nutritional deficiency disease.